Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols
نویسندگان
چکیده
منابع مشابه
Three-component metal-free arylation of isocyanides.
Though the efficiency of isocyanides as strong ligands for transition metals was recognized very early, the disclosure of metal-catalyzed arylation of isocyanides has only been explored quite recently. In most of these studies, the formation of a metal/aryl complex starting from aryl iodide or bromide is followed by isocyanide insertion and trapping of the metal/imidoyl complex with various nuc...
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T3P/DMSO is shown to be an effective and mild reagent for the one-pot synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones from a variety of alcohols. Alcohols are oxidized in situ to aldehydes under mild conditions, which undergo a three-component reaction with N,N'-dimethylbarbituric acid and various isocyanides to afford furo[2,3-d]pyrimidine-2,4(1H,3H)-diones in good yields.
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In this research, an efficient synthesis toward 2-(2-((4-Methoxybenzoyl)imino)-4-(4-methoxyphenyl)thiazol-3(2H)-yl)-2-phenylacetic acid via a three-component tandem reaction using aroylisothiocyanate, phenyl glycine, and 4-methoxyphenacyl bromide in an ionic liquid (IL) has been described. 1-Methyl-3-pentylimidazolium bromide (IL) has been employed as a recyclable green solvent. The work-up pro...
متن کاملReaction between 3-hydroxy pyridine alkyl isocyanides and dialkyl acetylenedicarboxylate: synthesis of 4H-chromenes
The reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields.
متن کاملReaction between 3-hydroxy pyridine alkyl isocyanides and dialkyl acetylenedicarboxylate: synthesis of 4H-chromenes
The reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields
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ژورنال
عنوان ژورنال: Frontiers in Chemistry
سال: 2019
ISSN: 2296-2646
DOI: 10.3389/fchem.2019.00345